Skip to main content

Walter J. Chazin, Ph.D.

  • Chancellor's Professor of Medicine
  • Professor of Biochemistry
  • Professor of Chemistry
  • Director, Vanderbilt University Center for Structural Biology
  • Director, Molecular Biophysics Training Program

Phone

615-936-2210

Email

walter.chazin@vanderbilt.edu
Vanderbilt University Medical Center
5140 MRB III, Suite 5140
Nashville, TN 37232

Walter J. Chazin, Ph.D.

  • Chancellor's Professor of Medicine
  • Professor of Biochemistry
  • Professor of Chemistry
  • Director, Vanderbilt University Center for Structural Biology
  • Director, Molecular Biophysics Training Program

615-936-2210

walter.chazin@vanderbilt.edu

Vanderbilt University Medical Center
5140 MRB III, Suite 5140
Nashville, TN 37232

Profile

My research interests fall under the general theme of understanding the structural basis for recognition, biochemical function and biological specificity of proteins and nucleic acids. My background in chemistry frames the way I think, but the deciding factor for choosing problems is not the approach, but rather the biomedical problem. Another key characteristic is tight coupling of our research to functional analysis. This strategy is by nature very collaborative and collegial, and has stimulated involvement in several multi-investigator research programs.

Our structural biology research focuses on the cutting edge of the technology and its application to increasingly complex systems. A significant part of our research is now devoted to multi-protein complexes, with programs studying various aspects of genome maintenance ranging from DNA replication to damage response and repair.

Education

  • Ph.D., Concordia University, Montreal, Quebec, Canada (1983)
  • B.Sc., McGill University, Montreal, Quebec, Canada (1975)

Postgraduate Training

  • Postdoc, Biophysics, E.T.H. Honggerberg, Zurich, Switzerland (1983-1985)
  • Postdoc, Structural Biology, The Scripps Research Institute, La Jolla, CA (1986-1987)

Research Emphasis

structural biology; protein dynamics; DNA replication; DNA repair; calcium signal transduction; protein ubiquitination; microbial pathogeneisis; calmodulin; calprotectin; replication protein A; DNA primase; XPA; XPC; S100 proteins; polymerase switching; cancer; diabetes; innate immunity; inflammation; chemical biology; small molecule discovery

Research Description

Research in my laboratory uses a multi-disciplinary, collaborative and structurally-oriented approach to address key problems in biology and medicine. At the molecular level, we study the structure and dynamics of proteins and their complexes with other proteins, nucleic acids and small molecule ligands. My independent career began as a biomolecular NMR spectroscopist, but our laboratory is now an integrated structural biology lab that uses many structural, biophysical and biochemical techniques, including calorimetry, fluorescence spectroscopy, X-ray crystallography, X-ray/neutron scattering, electron microscopy, computation, and biochemical assays in vitro and in cells. Our studies are greatly enhanced by numerous collaborators at Vanderbilt, around the country and across the world. Research areas include genome maintenance (DNA replication, damage response and repair), innate immunity and the host-pathogen struggle, and calcium regulation of cardiac ion channels.

Publications

Have any questions? Contact Us 1-877-936-8422 for more information