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VICC News

Long-Term Follow Up Pinpoints Side Effects of Treatments for Prostate Cancer Patients

A 10-year follow-up study of nearly 2,500 U.S. men who received prostate cancer treatment will help inform decision-making in terms of treatments and side effects for a diverse population. The CEASAR (Comparative Effectiveness Analysis of Surgery and Radiation for Localized Prostate Cancer) study, coordinated by VUMC, is a multisite research study conducting long-term follow-up on men who were diagnosed with localized prostate cancer between 2011 and 2012.


Thursday, February 1st, 2024
Molecular Profiles of Tissue Plus Circulating Tumor DNA Can Better Guide Cancer Care

The current standard of care for identifying targetable mutations in cancer treatment is to conduct molecular profiles on tumor tissue samples, but a study published Monday in JAMA Network Open authored by Wade Iams, MD, and colleagues indicates that adding liquid biopsy testing for circulating tumor DNA mutations increases targetable mutation detection rates.


Thursday, February 1st, 2024
3D Ingenuity: Surgeon develops visual aid for real-time pathology consults

Michael Topf, MD, Assistant Professor of Otolaryngology-Head and Neck Cancer Surgery at Vanderbilt wondered why computer-aided design (CAD) technology hadn’t made it into operating rooms as a visual aid for real-time consultations... So he decided to create it.


Thursday, February 1st, 2024
Exceptional Growth for Amyloidosis Care

When the Vanderbilt Amyloid Multidisciplinary Program (VAMP) launched in 2011, it was the first center in Tennessee dedicated to patients with amyloidosis – a rare, systemic disorder that encompasses myriad presentations and organ dysfunctions. Since then, VAMP has paved the way to coordinated care as a major referral center in the southeastern United States, growing to include over a dozen collaborating specialists working to provide structured, multidisciplinary care to adults navigating an amyloidosis diagnosis.


Wednesday, January 31st, 2024
New members of Academy for Excellence in Clinical Medicine selected

Vanderbilt University School of Medicine Academy for Excellence in Clinical Medicine (AECM) has selected 25 new members.


Friday, December 15th, 2023
Clinical trial shows efficacy for atezolizumab combined with carboplatin

Immunotherapy in combination with chemotherapy has become an important therapeutic treatment option in some patients with metastatic breast cancer. Which patients will benefit the most, however, remains unclear; current biomarkers such as PD-L1 that are used to predict response are mediocre at best.


Friday, December 15th, 2023
New members of Academy for Excellence in Clinical Medicine selected

Vanderbilt University School of Medicine Academy for Excellence in Clinical Medicine (AECM) has selected 25 new members.


Friday, December 15th, 2023
New members of Academy for Excellence in Clinical Medicine selected

Vanderbilt University School of Medicine Academy for Excellence in Clinical Medicine (AECM) has selected 25 new members.


Friday, December 15th, 2023
Coffey and Lau Colorectal cancer 'cartography' reveals an avenue to improved immunotherapy

Vanderbilt University Medical Center researchers have discovered why most colorectal tumors escape detection and destruction by the body's immune system.


Monday, December 11th, 2023
Coffey Vanderbilt research presented at Cancer Moonshot meet

Vanderbilt Colorectal cancer expert Bob Coffey, MD, was recently invited to present his research to representatives of President Joe Biden’s reignited Cancer Moonshot initiative.


Friday, December 8th, 2023
Gut microbiota metabolite protects against obesity: study
Vanderbilt researchers have discovered that beneficial bacteria in the small intestines produce a compound that protects against obesity.
Friday, December 8th, 2023
3D Ingenuity
Three-dimensional scanning and printing systems are now utilized for purposes ranging from same-day dental crowns to prosthetic limbs, so Michael Topf, MD, wondered why computer-aided design (CAD) technology hadn’t made it into operating rooms as a visual aid for real-time consultations.  Surgeons communicate via phone and are dependent upon verbal descriptions from pathologists for guidance […]
Thursday, November 30th, 2023
VUMC scientists discover key step to kidney fibrosis

Researchers at Vanderbilt University Medical Center for the first time have shown that activation of the epidermal growth factor receptor (EGFR) is essential for the development of kidney fibrosis, tissue scarring following injury that can lead to kidney failure.


Tuesday, November 21st, 2023
Tumor antigens key to improving cancer immunotherapy: study Tumor antigens key to improving cancer immunotherapy study

Vanderbilt researchers are working to better design immune therapies that attack tumors without also attacking healthy normal tissue in patients.


Friday, November 17th, 2023
Ken Lau named 2023 Stanley Cohen Innovation Fund Awardee

Ken Lau, professor of cell and developmental biology, has been selected to receive a one-year research award from the Stanley Cohen Innovation Fund.


Tuesday, November 7th, 2023
Crowe, Osheroff honored by AAMC Crowe Osheroff honored by AAMC

Vanderbilts James E. Crowe Jr MD and Neil Osheroff PhD are among 12 individuals honored by the Association of American Medical Colleges during its 2023 Awards Recognition Event.


Monday, October 30th, 2023
VUMC to help engage more study participants in research decisions

Human research will be more equitable, inclusive and stronger if the people who are participants in studies also help plan and guide the direction of those studies.


Wednesday, October 25th, 2023
VUMC initiative to address social drivers of health
Vanderbilt University Medical Center has received a federal grant to incorporate social drivers of health into adult primary care with the aim of improving outcomes for patients with multiple chronic conditions.
Thursday, October 19th, 2023
Study finds new genetic susceptibilities for colon cancer

Vanderbilt researchers at have found new genes that put people at higher risk for colon cancer and rectal cancer.


Tuesday, September 12th, 2023
New reference tool supports replication of DNA biobank studies
Vanderbilt researchers created a phenotype-genotype reference map to assess data quality in DNA biobanks.
Thursday, August 31st, 2023
Study finds hallmarks of T cell exhaustion within hours of tumor exposure
Vanderbilt researchers found that T cells become exhausted within hours of encountering a tumor, challenging existing ideas about how T cells become dysfunctional.
Wednesday, August 23rd, 2023
Karen Winkfield named a fellow of the American Society for Radiation Oncology
Karen Winkfield, MD, PhD, executive director of the Meharry-Vanderbilt Alliance, has been named a fellow of the American Society for Radiation Oncology.
Tuesday, August 1st, 2023
Nancy Cox receives American Society of Human Genetics Leadership Award

Nancy Cox PhD director of the Vanderbilt Genetics Institute is the recipient of the 2023 ASHG Leadership Award from the American Society of Human Genetics.


Wednesday, July 26th, 2023
International workgroup of geneticists issues CHEK2 guidelines

International workgroup issues additional guidance on how to manage patients who carry inherited CHEK2 gene mutations that put them at a higher risk for cancer.


Wednesday, July 26th, 2023
Marshaling First-Line Immunotherapy for CRC
Kristen Ciombor, M.D., reflects on recent wins and opportunities ahead in the precision targeting of colorectal cancer.
Wednesday, July 26th, 2023
Research Snapshot: DNA replication discovery opens pathways to understanding and treating cancer, aging and degenerative disease

An international collaboration led by biochemist David Cortez reached revelatory conclusions in exploration of how cells tolerate DNA damage and genome instability. Est. reading time: 2 mins.


Tuesday, May 23rd, 2023
Research identifies new target that may prevent blood cancer Research identifies new target that may prevent blood cancer

An international coalition of biomedical researchers co-led by Vanderbilts Alexander Bick MD PhD has determined a new way to measure the growth rate of precancerous clones of blood stem cells that one day could help doctors lower their patients risk of blood cancer.


Wednesday, April 12th, 2023
New dean of Basic Sciences aims to take Vanderbilt to the next level in biomedical research, drug discovery
Whether working on dynamic discoveries in the lab, connecting with students and faculty or pursuing his passion for nature photography, acclaimed biomedical researcher John Kuriyan is inspired by his recent move to join Vanderbilt as the new dean of the School of Medicine Basic Sciences and Distinguished University Professor.
Monday, April 3rd, 2023
Study explores new urinary tract infection treatment

Vanderbilt's Neil Osheroff, PhD, is part of an international research collaboration resulting in what is on track to be the first new antibiotic treatment for uncomplicated urinary tract infections in more than 20 years.


Thursday, February 23rd, 2023
Winkfield to direct Meharry-Vanderbilt Alliance
Karen Winkfield, MD, PhD, associate professor of Radiation Oncology at Wake Forest University, associate director for Community Outreach and Engagement, and director of the Office of Cancer Health Equity at Wake Forest Baptist Comprehensive Cancer Center, has been named the new executive director of the Meharry-Vanderbilt Alliance.
Friday, September 3rd, 2021
Wei Zheng Study incorporates genetics with smoking history to identify high-risk smokers for lung cancer screening
A study by Vanderbilt researchers that analyzed both smoking history and genetic risk variants for lung cancer supports modifying current guidelines to include additional smokers for lung cancer screening.
Tuesday, March 9th, 2021
Convalescent plasma improved survival in COVID-19 patients with blood cancers Convalescent plasma improved survival in COVID-19 patients with blood cancers
Treatment with convalescent plasma vastly improved the survival rate of patients hospitalized for COVID-19 who also had hematologic malignances that compromise the immune system, according to new data released by the COVID-19 and Cancer Consortium (CCC19).
Friday, February 5th, 2021
Gene network for leukemia factor Gene network for leukemia factor
 

Transcription factors — proteins that regulate gene expression — play critical roles in cell fate decisions and are frequent targets of mutation in a variety of human cancers.


Thursday, February 4th, 2021
Potential biomarker for IBD severity, cancer risk identified Potential biomarker for IBD severity, cancer risk identified
A selenium transport protein produced in the colon is underexpressed in patients with ulcerative colitis and helps protect against colitis-associated cancer in an animal model, Vanderbilt investigators have discovered.
Thursday, February 4th, 2021
A protein that can melt tumors discovered at Vanderbilt A protein that can melt tumors discovered at Vanderbilt
For the second time, cancer researchers at Vanderbilt have discovered a protein that—when genetically manipulated to impede it from interacting with a gene responsible for cancer genesis—effectively melts tumors in days.
Wednesday, January 27th, 2021
VUMC, Case Western apply artificial intelligence to “customize” oral cancer treatment VUMC, Case Western apply artificial intelligence to “customize” oral cancer treatment
Researchers at Vanderbilt University Medical Center and Case Western Reserve University in Cleveland have been awarded a five-year, $3.3 million grant by the National Cancer Institute to apply artificial intelligence (AI) to help customize treatment for oral cancer patients.
Tuesday, January 5th, 2021
Pal named to cancer research national leadership posts Pal named to cancer research national leadership posts
Tuya Pal, MD, Ingram Professor of Cancer Research and associate director for Cancer Health Disparities at Vanderbilt-Ingram Cancer Center, has been named to two cancer research leadership posts.
Monday, December 28th, 2020
Study reveals new strategy for reducing tumor growth, metastasis Study reveals new strategy for reducing tumor growth, metastasis
A team of Vanderbilt investigators has discovered that blocking a certain signaling pathway boosts antitumor immunity and reduces tumor growth and metastasis in models of breast cancer and melanoma.
Thursday, December 17th, 2020
Cortez named interim chair of the Department of Biochemistry; York named Impossible Foods chief science officer Cortez named interim chair of the Department of Biochemistry; York named Impossible Foods chief science officer
David Cortez, PhD, Richard N. Armstrong Professor of Innovation in Biochemistry and professor of biochemistry, has been named interim chair in the Department of Biochemistry beginning Jan. 1, 2021.
Tuesday, December 8th, 2020
Peterson tapped to direct VUMC’s Center for Precision Medicine Peterson tapped to direct VUMC’s Center for Precision Medicine
Josh Peterson, MD, MPH, professor of Biomedical Informatics and Medicine, has been named director of the Center for Precision Medicine at Vanderbilt University Medical Center, effective since Oct. 1.
Wednesday, November 18th, 2020
New drug for metastatic colorectal cancer enters phase 3 trial New drug for metastatic colorectal cancer enters phase 3 trial
A new therapy for metastatic colorectal cancer that has been granted fast track designation by the U.S. Food and Drug Administration is being tested in a phase 3 clinical trial at Vanderbilt-Ingram Cancer Center.
Wednesday, November 18th, 2020
V Scholar Award to support Byndloss’ cancer research V Scholar Award to support Byndloss’ cancer research
Mariana Byndloss, DVM, PhD, assistant professor of Pathology, Microbiology and Immunology, has received a V Scholar Award from the V Foundation for Cancer Research.
Wednesday, November 18th, 2020
Breast cancer treatment in older women Breast cancer treatment in older women
Breast-conserving surgery (BCS) plus radiotherapy is the standard-of-care for women diagnosed with early-stage breast cancer.
Thursday, November 12th, 2020
New therapeutic target for lung cancer New therapeutic target for lung cancer
Continuous activation of cell surface receptors increases signaling that can promote oncogenic transformation. One receptor, EphA2, has been identified as a driver of lung cancer, but its interacting partners are not well characterized.
Thursday, November 12th, 2020
New therapeutic target for lung cancer New therapeutic target for lung cancer
Continuous activation of cell surface receptors increases signaling that can promote oncogenic transformation. One receptor, EphA2, has been identified as a driver of lung cancer, but its interacting partners are not well characterized.
Thursday, November 12th, 2020
Screening younger women for hereditary cancers may be cost effective Screening younger women for hereditary cancers may be cost effective
Population-wide screening for genetic variants linked to hereditary breast and ovarian cancer may be cost effective in women between the ages of 20 and 35, according to a study published in JAMA Network Open.
Thursday, November 5th, 2020
Brian Rini Rini to lead NCI study of COVID-19 in cancer patients
Brian Rini, MD, is leading a study launched by the National Cancer Institute (NCI) that will closely monitor cancer patients who acquire COVID-19 with the goal of providing highly detailed data to guide future care.
Thursday, October 29th, 2020
Lovly to chair foundation’s scientific leadership board Lovly to chair foundation’s scientific leadership board
Christine Lovly, MD, PhD, Ingram Associate Professor of Cancer Research, has been named incoming chair of GO2 Foundation’s Scientific Leadership Board (SLB).
Thursday, October 29th, 2020
Variety of influences helped shape Birch’s medical career Variety of influences helped shape Birch’s medical career
Andrea Birch was 9 years old and on top of the world.
Thursday, October 22nd, 2020
Park named director of Hematology and Oncology at VICC Park named director of Hematology and Oncology at VICC
After serving as interim director since Jan. 1, Ben Ho Park, MD, PhD, Donna S. Hall Professor of Breast Cancer Research at Vanderbilt University Medical Center, has been named director of the Division of Hematology and Oncology.
Wednesday, October 21st, 2020
Study finds AI can categorize cancer risk of lung nodules Study finds AI can categorize cancer risk of lung nodules
 

Computed tomography scans for people at risk for lung cancer lead to earlier diagnoses and improve survival rates, but they can also lead to overtreatment when suspicious nodules turn out to be benign.


Thursday, May 7th, 2020
Study tracks genomics of lung tumor behavior Study tracks genomics of lung tumor behavior
 

A study by Vanderbilt researchers has identified genomic alterations in early stage adenocarcinomas of the lung that may indicate whether the lesions develop into aggressive tumors.


Thursday, April 9th, 2020
3d rendered illustration of blood cells with droplets HDL-cholesterol and breast cancer risk
Genetic analyses suggest that high circulating HDL-cholesterol levels may increase breast cancer risk — a surprising finding since increased HDL-cholesterol is thought to be healthy.
Friday, January 24th, 2020
stomach illustration VUMC study sheds light on gastric cancer development
VUMC researchers have created the world’s first laboratory model of precancerous changes in the lining of the stomach, a scientific tour de force that is helping to unlock the mysteries of gastric cancer development.
Friday, January 17th, 2020
Daniel Barocas Study examines prostate cancer treatment decisions
 

A five-year follow-up study of U.S. men who received prostate cancer treatment is creating a road map for future patients to clarify expectations and enable men to make informed choices about care.


Friday, January 3rd, 2020
cancer in genetic code Study finds breast cancer recurrence score has different implications for men
A study published last year offered good news for women with early-stage ER-positive breast cancer who scored at intermediate risk for recurrence. However, a new study finds this conclusion may not directly apply to male patients with the same type of breast cancer
Monday, December 23rd, 2019
Ann Richmond Richmond receives legacy award from Society for Leukocyte Biology
Ann Richmond, PhD, Ingram Professor of Cancer Research, is the 2019 recipient of the Society for Leukocyte Biology Legacy Award.
Friday, December 13th, 2019
Justin Balko Balko lands Mary Kay Foundation grant for breast cancer research
Vanderbilt-Ingram Cancer Center's Justin Balko, PharmD, PhD, has received a $100,000 research grant from the Mary Kay Foundation.
Friday, December 6th, 2019
dividing cell Understanding cell division
Vanderbilt researchers have uncovered another piece in the puzzle of how cells divide — a process that goes awry in cancer cells.
Tuesday, November 19th, 2019
Vivian Weiss Grant bolsters Weiss’ pediatric thyroid cancer research
Vivian Weiss, MD, PhD, has been named a 2020 V Scholar and will receive $200,000 from the V Foundation for Cancer Research.
Thursday, November 7th, 2019
Charles Manning Project seeks new way to assess immunotherapy effectiveness
GE Healthcare has awarded researchers $2.5 million in funding to develop PET tracer that will determine the effectiveness of immunotherapy in patients early in their treatment course.
Thursday, November 7th, 2019
Travis Osterman VUMC’s Osterman awarded Microsoft Investigator Fellowship
 

Travis Osterman, DO, MS, has been awarded a Microsoft Investigator Fellowship.


Thursday, November 7th, 2019
Kimryn Rathmell Rathmell receives 2019 Eugene P. Schonfeld Award
The Kidney Cancer Association is recognizing the research accomplishments and leadership achievements of W. Kimryn Rathmell, MD, PhD, with its top honor, the Eugene P. Schonfeld Award.
Wednesday, November 6th, 2019
Cathy Eng New Physician Spotlight: Cathy Eng
Cathy Eng, MD, a national and international leader in gastrointestinal medical oncology, was recruited to VUMC from The University of Texas MD Anderson Cancer Center in Houston.
Friday, November 1st, 2019
Jeffrey Rathmell Rathmell lands award from Lupus Research Alliance
Jeffrey Rathmell, PhD, is a 2019 recipient of the Dr. William E. Paul Distinguished Innovator Award in Lupus and Autoimmunity.
Thursday, October 31st, 2019
yogurt High fiber, yogurt diet associated with lower lung cancer risk
A diet high in fiber and yogurt is associated with a reduced risk for lung cancer, according to a study by Vanderbilt University Medical Center researchers.
Monday, October 28th, 2019
Pietenpol, Wilson land Komen cancer research support Pietenpol, Wilson land Komen cancer research support
Two Vanderbilt-Ingram Cancer Center investigators have received financial support from Susan G. Komen for breast cancer research.
Thursday, October 24th, 2019
Pietenpol, Wilson land Komen cancer research support Pietenpol, Wilson land Komen cancer research support
Two Vanderbilt-Ingram Cancer Center investigators have received financial support from Susan G. Komen for breast cancer research.
Thursday, October 24th, 2019
3d DNA illustration Completing DNA synthesis
James Dewar and colleagues have identified a role for the enzyme topoisomerase II in reducing replication errors during the final stage of DNA synthesis.
Monday, October 21st, 2019
Xiao Ou Shu Study finds men have higher mortality rate after breast cancer diagnosis
A new study shows men with breast cancer are more likely to die than their female counterparts, across all stages of disease.
Thursday, October 17th, 2019
Ronald Cowan Study examines pain processing in co-occurring cancer, Alzheimer’s disease
 

A new multisite study will examine whether co-occurring Alzheimer’s disease and stage 4 breast or prostate cancer alters pain perception, potentially leading to undertreated cancer pain.


Thursday, October 10th, 2019
A step toward gastric cancer A step toward gastric cancer
New research findings provide insight into the detrimental events that develop in response to H. pylori infection.
Thursday, October 3rd, 2019
Kimryn Rathmell VICC’s Rathmell honored with Louisa Nelson Award
Kimryn Rathmell, MD, PhD, director of the Division of Hematology and Oncology, received an award that honors women who embody the achievement, vision and inspiration of the founder of a local distillery.
Thursday, October 3rd, 2019
3D Illustration of Human Heart Anatomy Study identifies targeted therapy’s cardiac risks
After a recent study showed that chronic lymphocytic leukemia patients who received ibrutinib as a frontline treatment had a 7% death rate, a new study offers a clearer picture on the reasons for the deaths.
Thursday, October 3rd, 2019
Effort seeks to enhance cancer screening for Hispanic/Latina women Effort seeks to enhance cancer screening for Hispanic/Latina women
Providing access to a culturally appropriate community health worker during breast cancer screenings may impact elements of patient care and satisfaction among Hispanic/Latina women.
Wednesday, September 25th, 2019
telemedicine New telehealth initiative aims to enhance cancer care in rural areas
VUMC is leading an effort to improve cancer care in rural areas with a telehealth initiative supported with a $3.3 million grant from the National Cancer Institute.
Thursday, September 19th, 2019
medical samples Potential prostate cancer biomarkers
An analysis of more than 140,000 people of European ancestry has identified blood protein biomarkers associated with prostate cancer risk.
Thursday, September 19th, 2019
Christina Bailey Bailey to direct general surgery residency program
Christina Bailey, MD, MSCI, assistant professor of Surgery, has been named the new program director of the general surgery residency training program in the Department of Surgery, Section of Surgical Sciences.
Monday, September 9th, 2019
DNA analysis Study backs genetic testing for all metastatic breast cancer patients
Testing for all metastatic breast cancer patients may be an optimal strategy for identifying additional patients with increased risk as well as response to targeted therapies.
Friday, September 6th, 2019
intestines illustration Colorectal cancer researchers receive SPORE funding
Colorectal cancer researchers from Vanderbilt-Ingram Cancer Center (VICC) have been awarded a Specialized Program of Research Excellence grant from the National Cancer Institute (NCI).
Saturday, August 31st, 2019
women in pink Grant strengthens breast cancer research efforts
Breast cancer researchers at Vanderbilt-Ingram Cancer Center have secured a fourth round of continuous Specialized Program of Research Excellence funding.
Saturday, August 31st, 2019
3D Illustration of Pancreas Pancreatic cancer clue
Inflammation synergizes with a cell’s intrinsic genetic program to promote the development of pancreatic cancer.
Friday, August 30th, 2019
colon cancer cells Protein’s role in inflammation-related cancer studied
Investigators are exploring the molecular mechanisms behind the association of chronic inflammation and colon cancer.
Friday, August 30th, 2019
melanoma on forehead Potential second-line melanoma treatment identified
A study led by Anna Vilgelm, MD, PhD, and Ann Richmond, PhD, has identified a possible second-line treatment for melanoma patients.
Friday, August 30th, 2019
prostate cancer cells New prostate cancer treatment concept
Combining immunotherapy and radiation therapy may be a powerful treatment approach for castration-resistant prostate cancer.
Friday, August 30th, 2019
fibroblast and collagen New window on fibrosis
A previously unrecognized role for a cell surface receptor may open new therapeutic options for the treatment of fibrotic diseases.
Friday, August 9th, 2019
Michael Savona Grant bolsters research on myelodysplastic syndromes
Michael Savona, MD, professor of Medicine and Cancer Biology, and director of Hematology Research at Vanderbilt-Ingram Cancer Center, has received a competitive grant award from the Edward P. Evans Foundation.
Friday, August 9th, 2019
cancer metastasis illustration Cellular soldiers designed to kill cancer cells that get loose during surgery, stop metastasis
Cellular soldiers created using the body’s own defenses can track down and kill escaping cancer cells during surgeries, preventing metastasis and saving lives, a Vanderbilt University biomedical engineer has discovered, particularly in cases of triple negative breast cancer.
Friday, July 26th, 2019
dna repair illustration Team’s study reveals details of new DNA repair pathway
Investigators have discovered how a DNA repair pathway protein shields sites of damage to avoid mutations and maintain genome integrity.
Friday, July 26th, 2019
brain scan Encephalitis identified as rare toxicity of immunotherapy treatment
Researchers are chronicling rare but serious toxicities that may occur with immune checkpoint inhibitors, the most widely prescribed class of immunotherapies.
Monday, July 22nd, 2019
brain scan Encephalitis identified as rare toxicity of immunotherapy treatment
Researchers are chronicling rare but serious toxicities that may occur with immune checkpoint inhibitors, the most widely prescribed class of immunotherapies.
Monday, July 22nd, 2019
Jeffrey Rathmell Center for Immunobiology grows, bolsters program
The Vanderbilt Center for Immunobiology has relaunched its mission with a greater focus on human immunology, an endeavor supported by additional researchers, more funding support and designation as a Center of Excellence.
Friday, July 19th, 2019
bandages A critical factor for wound healing
Vanderbilt-Ingram Cancer Center scientists have discovered a role for a tumor suppressor protein in skin wound healing.
Friday, July 19th, 2019
Neil Osheroff International Association of Medical Science Educators honors Osheroff
Neil Osheroff, PhD, received the Distinguished Career Award for Excellence in Teaching and Educational Scholarship from the International Association of Medical Science Educators (IAMSE).
Thursday, July 11th, 2019
imaging scanner Potential probe for early ovarian cancer
Larry Marnett and colleagues have developed what may become the first agent for targeted PET imaging of cancer tissues, such as ovarian cancer, that express high levels of the COX-1 enzyme.
Saturday, June 29th, 2019
African American patient with doctor Health disparity for blacks exists within lung screening guidelines
The U.S. Preventive Services Task Force (USPSTF) guidelines that determine which smokers qualify for CT scans exclude significant numbers of African Americans who develop lung cancer, a health disparity that merits modifications to lung cancer screening criteria, according to a study from Vanderbilt researchers.
Saturday, June 29th, 2019
Mother and teenager Childhood cancer: how it’s different than for adults
The nature of childhood cancer is different than adult cancer, and so is the approach to treatment.
Saturday, June 29th, 2019
Shari Barkin Academic Pediatric Association honors Barkin
 

Shari Barkin, MD, MSHS, division chief of General Pediatrics at Monroe Carell Jr. Children’s Hospital at Vanderbilt, was honored recently with the 2019 Academic Pediatric Association (APA) Research Award.


Thursday, May 30th, 2019
Gore, King elected to 2019 IAMBE Class of Fellows Gore, King elected to 2019 IAMBE Class of Fellows
John Gore, PhD, director of the Vanderbilt University Institute of Imaging Science (VUIIS), and Michael King, PhD, J. Lawrence Wilson Professor and chair of the Department of Biomedical Engineering at Vanderbilt University, were recently elected to the International Academy of Medical and Biological Engineering (IAMBE) 2019 Class of Fellows in recognition of their contributions in the field of medical and biological engineering.
Thursday, May 30th, 2019
Sheila Ridner and patient Technology better than tape measure for identifying lymphedema risk
 

Bioimpedance spectroscopy (BIS) is better than a tape measure for assessing a woman’s risk for developing lymphedema, painful swelling in the arm after breast cancer surgery, according to interim results of a recent study.


Friday, May 17th, 2019
William Tansey Researchers putting the brakes on lethal childhood cancer
 

A recent study suggests that blocking the MYC protein could be “unexpectedly effective” in treating malignant rhabdoid tumor (MRT) is one of the most aggressive and lethal childhood cancers.


Friday, May 3rd, 2019
yin yang symbol The yin and yang of cell signaling
 

Changes in enzymes involved in lysophospholipid signaling can activate a pathway implicated in development of cancer, a recent study suggests.


Thursday, February 14th, 2019
virus illustration RNA processing and antiviral immunity
A recent study in Nature Communications defines the in vivo substrates of RIG-I like receptors (RLRs) during an oncogenic virus infection and reveals a relationship between cellular RNA processing and an innate antiviral immune response.
Friday, December 14th, 2018
Breast cancer-killing RIG Breast cancer-killing RIG
A recent study in the journal Cancer Research demonstrates that a RIG-I agonist has potent immunogenic and therapeutic effects in breast cancer.
Friday, December 14th, 2018
Lung cancer Combination therapy improves small-cell lung cancer survival
Patients who received atezolizumab in addition to standard chemotherapy lived two months longer than those treated with chemotherapy alone, according to a recent study published in the New England Journal of Medicine.
Friday, October 26th, 2018
Consuelo Wilkins Grant to develop ways to measure medical mistrust in African-American men
Vanderbilt University Medical Center has been awarded a two-year, $250,000 grant by The Robert Wood Johnson Foundation to develop new ways to measure trust in African-American men as it relates to health care.
Friday, August 3rd, 2018
colon cancer cells SMAD4 clue to colon cancer
A recent study has linked inflammation-driven carcinogenesis in the colon to loss of an important signaling protein called SMAD4.
Friday, July 6th, 2018
Consuelo Wilkins Wilkins takes key role in national ‘All of Us’ precision medicine effort
Consuelo Wilkins, MD, MSCI, has been appointed director of a new Engagement Core to support the design, implementation and governance of the national All of Us Research Program, an ambitious effort led by the National Institutes of Health (NIH) to accelerate the prevention and treatment of illness through precision medicine.
Monday, April 30th, 2018
Ingrid Mayer VICC breast cancer leaders named Komen Scholars
Ingrid Mayer, MD, MSCI, Ingram Professor of Cancer Research and leader of the Breast Cancer Research Program, has been named a Komen Scholar for her leadership in breast cancer research. She is joined by Wayne Dornan, PhD, a patient research advocate at VICC, who will serve on the Advocates in Science Steering Committee for Susan G. Komen.
Friday, April 13th, 2018
Justin Balko Study seeks to boost breast tumor immune response
 

Targeting specific molecules in breast tumors, called methylating agents, can turn up the immune response, potentially making tumors responsive to immunotherapy, suggests a new study published in Nature Communications.


Thursday, February 8th, 2018
glutamine structure VUMC researchers find a way to ‘starve’ cancer
 

Researchers at Vanderbilt University Medical Center (VUMC) have demonstrated for the first time that it is possible to starve a tumor and stop its growth with a newly discovered small compound that blocks uptake of the vital nutrient glutamine.


Thursday, January 18th, 2018
medical samples Liquid biopsies help reveal lung cancer mutations
 

Cancer investigators led by researchers at Vanderbilt-Ingram Cancer Center have co-developed a liquid biopsy blood-based assay used to identify specific gene mutations associated with the development or relapse of small-cell lung cancer (SCLC)


Thursday, November 2nd, 2017
Ingrid Mayer Study to test combination therapy for breast cancer
Vanderbilt-Ingram Cancer Center has received $2.3 million to fund a clinical research trial testing a combination of three immunotherapy compounds for patients with a specific type of advanced breast cancer.
Friday, October 27th, 2017
colon cancer cells Researchers find novel mechanism of resistance to anti-cancer drugs
The targeted anti-cancer therapies cetuximab and panitumumab are mainstays of treatment for advanced colorectal cancer, the second leading cause of cancer-related deaths in the United States. However, many patients have tumors with genetic mutations that make them resistant to these anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, or the cancers develop resistance during treatment.
Friday, October 20th, 2017
antibodies monoclonal HDAC3 role in B-cell development
 

Histone deacetylases (HDACs) are enzymes that modulate gene expression and have important roles in development and disease. HDAC inhibitors are active against lymphoma, and understanding the roles of specific HDACs is important for further therapeutic development. Scott Hiebert, Ph.


Monday, August 7th, 2017
Ariella Hanker Investigators match novel cancer mutations with potential therapies
Research led by Vanderbilt-Ingram Cancer Center (VICC) investigators may have solved a mystery about why a targeted therapy stops working in a small group of breast cancer patients. They identified a novel gene mutation that develops in the tumors, and then found a different cancer drug that appears to treat the newly identified mutation. The […]
Monday, August 7th, 2017
Drivers of breast cancer metastasis Drivers of breast cancer metastasis
Overexpression of HER2 (human epidermal growth factor receptor 2) is found in about 25 percent of breast cancers and is associated with poor outcomes. HER2-amplified breast cancers use signaling through a complex of proteins called mTORC2 to drive tumor formation, tumor cell survival and resistance to HER2-targeted therapies. Rebecca Cook, Ph.
Thursday, July 27th, 2017
Robert Coffey Coffey lands major NCI award to support colorectal cancer research
Vanderbilt’s Robert Coffey Jr., M.D.
Friday, June 9th, 2017
Horn to lead lung cancer combination therapy trial Horn to lead lung cancer combination therapy trial
Leora Horn, M.D., M.
Sunday, April 2nd, 2017
Breast cancer program lands new research grants Breast cancer program lands new research grants
Several investigators in Vanderbilt-Ingram Cancer Center’s (VICC) Breast Cancer Program have received grant awards to support translational research that may improve disease outcomes for patients. The grants totaling more than $3 million will fund mechanistic science and clinical trials designed to test novel therapy combinations and determine why some forms of breast cancer become resistant […]
Friday, March 24th, 2017
Study takes 3-D perspective on colorectal cancer Study takes 3-D perspective on colorectal cancer
Despite dramatic recent advances in treatment, colorectal cancer killed more than 49,000 Americans last year, according to the National Cancer Institute, making it the second most lethal malignancy after cancers of the lung and bronchus. Determined to reduce the death toll, researchers at Vanderbilt University Medical Center recently put on their 3-D “glasses” and took […]
Friday, March 24th, 2017
McDonald lab Metastatic pancreatic cancer ‘reprograms’ for malignancy
Metastatic pancreatic cancer — cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths — changes its metabolism and is “reprogrammed” for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics. It may be possible to reverse the malignant reprogramming to treat metastatic pancreatic cancer, […]
Thursday, January 19th, 2017
Study details rare heart risk of certain cancer therapies Study details rare heart risk of certain cancer therapies
Combination therapy using two approved immunotherapy drugs for cancer treatment may cause rare and sometimes fatal cardiac side effects linked to an unexpected immune response. In a study led by Vanderbilt University Medical Center (VUMC) investigators and published in the Nov. 3 issue of the New England Journal of Medicine, researchers describe two cases of […]
Monday, November 7th, 2016
Study details rare heart risk of certain cancer therapies Study details rare heart risk of certain cancer therapies
Combination therapy using two approved immunotherapy drugs for cancer treatment may cause rare and sometimes fatal cardiac side effects linked to an unexpected immune response. In a study led by Vanderbilt University Medical Center (VUMC) investigators and published in the Nov. 3 issue of the New England Journal of Medicine, researchers describe two cases of […]
Monday, November 7th, 2016
lung cancer VICC trial putting lung cancer therapy to the test
Vanderbilt-Ingram Cancer Center (VICC) is leading a Phase 3 global trial of a cancer therapy that was initially tested and validated in a VICC research laboratory. One of the first patients treated with the therapy came to VICC after a bump on the head led to an unexpected cancer diagnosis. That head injury may have […]
Thursday, October 20th, 2016
prostate ultrasound New prostate cancer therapy investigated at VUMC
Vanderbilt University Medical Center is the world’s first site to treat a patient in the TULSA-PRO Ablation Clinical Trial (TACT), which employs an emerging therapy that uses MRI guidance and robotically driven therapeutic ultrasound to obtain precise prostate cancer tissue ablation. Investigators, David Penson, M.D.
Thursday, September 22nd, 2016
prostate ultrasound New prostate cancer therapy investigated at VUMC
Vanderbilt University Medical Center is the world’s first site to treat a patient in the TULSA-PRO Ablation Clinical Trial (TACT), which employs an emerging therapy that uses MRI guidance and robotically driven therapeutic ultrasound to obtain precise prostate cancer tissue ablation. Investigators, David Penson, M.D.
Thursday, September 22nd, 2016
VICC investigators in spotlight at AACR conference VICC investigators in spotlight at AACR conference
A top Vanderbilt-Ingram Cancer Center (VICC) investigator recently met with Vice President Joe Biden regarding the National Cancer Moonshot Initiative, a major national program to identify, fund and accelerate the most promising research leading to cancer cures. Carlos L. Arteaga, M.
Thursday, May 19th, 2016
VICC investigators in spotlight at AACR conference VICC investigators in spotlight at AACR conference
A top Vanderbilt-Ingram Cancer Center (VICC) investigator recently met with Vice President Joe Biden regarding the National Cancer Moonshot Initiative, a major national program to identify, fund and accelerate the most promising research leading to cancer cures. Carlos L. Arteaga, M.
Thursday, May 19th, 2016
VICC investigators in spotlight at AACR conference VICC investigators in spotlight at AACR conference
A top Vanderbilt-Ingram Cancer Center (VICC) investigator recently met with Vice President Joe Biden regarding the National Cancer Moonshot Initiative, a major national program to identify, fund and accelerate the most promising research leading to cancer cures. Carlos L. Arteaga, M.
Thursday, May 19th, 2016
Study explores how some breast cancers resist treatment Study explores how some breast cancers resist treatment
A targeted therapy for triple-negative breast cancer (TNBC), the most aggressive form of breast cancer, has shown potential promise in a recently published study. TNBC is the only type of breast cancer for which there are no currently approved targeted therapies. The new study led by Vanderbilt-Ingram Cancer Center (VICC) investigators has identified gene alterations […]
Thursday, April 21st, 2016
Wade Hayes concert Singer’s concert honors care received at Cancer Center
A cancer patient’s gratitude toward his Vanderbilt-Ingram Cancer Center (VICC) physician led to a star-studded concert to benefit the Cancer Center. Colon cancer survivor and country artist Wade Hayes was joined by six-time CMA and ACM Female Vocalist of the Year Miranda Lambert, four-time Grammy and CMA Award-winning artist Steve Wariner and Kix Brooks, CMA […]
Thursday, March 24th, 2016
stem cell transplant VICC treats first patient in Tennessee with novel cellular immunotherapy
For the first time, Vanderbilt-Ingram Cancer Center (VICC) investigators have used a cancer patient’s own re-engineered immune cells to treat a form of blood cancer by stimulating the immune system. The new CAR-T investigational therapy (known as KTE-C19) is being studied in a clinical trial for patients with aggressive non-Hodgkin Lymphoma (NHL). The trial, called […]
Monday, February 29th, 2016