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mammography

Breast Cancer Research Program

The Breast Cancer Program places a strong emphasis on breast epithelial cell and molecular biology, basic science-driven translational and clinical research, and molecular epidemiology. Program members conduct research across a variety of disciplines and research focus areas, including: cellular signaling and molecular biology; breast pathology; genomic profiling; biomedical informatics; medical, surgical, and radiation oncology; clinical trial design; epidemiology; and supportive care studies.

RESEARCH THEMES

The Breast Cancer Program has expertise in and leads clinical trials related to:

Identifying the role of PI3K inhibitors in resistance to antiestrogens in ER+ breast cancer

Molecular sub-classification of triple negative breast cancer and discovery of novel treatment targets

Evaluating non-invasive imaging technologies to predict anti-cancer drug action and treatment response

Studying the role of ERBB3 in mammary gland development, transformation and adaptive resistance

Understanding the role of TGFβ in cancer stem-like behavior and tumor progression

Investigating obesity as a metabolic marker of breast cancer risk in African Americans

Discovering actionable therapy targets in drug-resistant breast tumors after neoadjuvant therapy

Leading innovative clinical trials with targeted therapies and combinations

Meet the Program Members

The Breast Cancer Research Program has more than 30 members from multiple basic science and clinical departments across Vanderbilt University and Medical Center. Ingrid Mayer, M.D., is the Program Leader and Clinical Director. 


Featured Publications

Program News

October 12, 2018

Cancer Center investigators awarded Komen grants

Vanderbilt-Ingram Cancer Center (VICC) investigators have received financial support from Susan G. Komen for breast cancer research.
July 2, 2018

Team identifies new gene candidates for breast cancer risk

A new study has identified 48 candidate susceptibility genes for breast cancer risk, including 14 genes at loci (chromosome regions) not yet reported for breast cancer.

Seminars & Events