Breast Cancer Research Program
The Breast Cancer Research Program has a strong emphasis on high-impact, collaborative, multi-disciplinary and mechanism-based research encompassing breast epithelial cell and molecular biology, genetics and genomics, immunotherapy, basic science-driven translational and clinical research, innovative clinical trials, and molecular epidemiology. Program members conduct research across a variety of disciplines and research focus areas, including: cellular signaling and molecular biology; breast pathology; genomic profiling; biomedical informatics; medical, surgical, and radiation oncology; clinical trial design; epidemiology; and supportive care studies.
The Breast Cancer Program has expertise in and leads clinical trials related to:
ER-Positive Breast Cancer
Identifying the role of PI3K inhibitors in resistance to antiestrogens in ER+ breast cancer
Triple-Negative Breast Cancer
Molecular sub-classification of triple negative breast cancer and discovery of novel treatment targets
Evaluating non-invasive imaging technologies to predict anti-cancer drug action and treatment response
Breast Development & Disease
Studying the role of ERBB3 in mammary gland development, transformation and adaptive resistance
Cancer Stem Cells
Understanding the role of TGFβ in cancer stem-like behavior and tumor progression
Disparities & Risk Factors
Investigating obesity as a metabolic marker of breast cancer risk in African Americans
Discovering actionable therapy targets in drug-resistant breast tumors after neoadjuvant therapy
Leading innovative clinical trials with targeted therapies and combinations
Meet the Program Members
The Breast Cancer Research Program includes around 30 members from multiple basic science and clinical departments across Vanderbilt University and Medical Center. Ingrid Mayer, M.D., M.S.C.I., and Ben Park, M.D., Ph.D., co-lead the program.
Clinical and genomic risk to guide the use of adjuvant therapy for breast cancer.
Sparano, J.A., Gray, R.J., Ravdin, P.M., Makower, D.F., Pritchard, K.I., Albain, K.S., Hayes, D.F., Geyer, C.E., Dees, E.C., Goetz, M.P., Olson, J.A., Lively, T., Badve, S.S., Saphner, T.J., Wagner, L.I., Whelan, T.J., Ellis, M.J., Paik, S., Wood, W.C., Keane, M.M., Gomez Moreno, H.L., Reddy, P.S., Goggins, T.F., Mayer, I.A. (BC), Brufsky, A.M., Toppmeyer, D.L., Kaklamani, V.G., Berenberg, J.L., Abrams, J. & Sledge, G.W.
N Engl J Med 380(25):2395-2405, 2019; PMC6709671.
A Critical Need for Better Cancer Immunotherapy Models: Are Organotypic Tumor Spheroid Cultures the Answer?
Balko JM (BC), Sosman JA.
Cancer Discov 2018 FEB 8(2):143-145 PMID:29431673.
MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
Lee KM, Giltnane JM, Balko JM (BC), Schwarz LJ, Guerrero-Zotano AL, Hutchinson KE, Nixon MJ, Estrada MV, Sánchez V, Sanders M (BC), Lee T, Gómez H, Lluch A, Pérez-Fidalgo JA, Wolf MM, Andrejeva G, Rathmell JC (HT), Fesik SW (ST), Arteaga CL
Cell Metab. 2017 OCT 3 26(4):633-647.e7 PMC5650077
Genomic profiling of ER(+) breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance
Giltnane JM, Hutchinson KE, Stricker TP (BC), Formisano L, Young CD, Estrada MV, Nixon MJ, Du L, Sanchez V, Ericsson PG, Kuba MG, Sanders M (BC), Mu XJ, Van Allen EM, Wagle N, Mayer IA (BC), Abramson VG (BC), Gόmez H, Rizzo M, Toy W, Chandarlapaty S, Mayer EL, Christiansen J, Murphy D, Fitzgerald K, Wang K, Ross JS, Miller VA, Stephens PJ, Yelensky R, Garraway L, Shyr Y (NP), Meszoely IM (BC), Balko JM (BC), Arteaga CL (BC)
Sci Transl Med 2017 AUG 9 9(402) PMC5723145
An Acquired HER2(T798I) Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer
Hanker AB (BC), Red Brewer M, Brewer MR, Sheehan JH (BC), Koch JP, Sliwoski GR, Nagy R, Lanman R, Berger MF, Hyman DM, Solit DB, He J, Miller V, Cutler RE, Lalani AS, Cross D, Lovly CM (TR), Meiler J (TR), Arteaga CL (BC)
Cancer Discov 2017 JUN 8 7(6):575-585 PMC5457707
Neoadjuvant Trials in ER(+) Breast Cancer: A Tool for Acceleration of Drug Development and Discovery.
Guerrero-Zotano AL, Arteaga CL (BC).
Cancer Discov 2017 JUN 7(6):561-574 PMC5497752.