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Lung cancer metastasis-National Cancer Institute \ Winship Cancer Institute of Emory University

Host-Tumor Interactions Research Program

Tumor growth, invasion, and metastasis depend not only on the tumor cell alone, but also on the complex interactions between the tumor cells and their host. The goal of the Host-Tumor Interactions Research Program is to develop a detailed and mechanistic understanding of not just the tumor cell and tumor mutations, but also all the components of the host microenvironment that influence cancer and the response to cancer therapy.

RESEARCH THEMES

With the goal of understanding how complex interactions between tumor cells and their host contribute to cancer, the Host-Tumor Interactions program focuses on four specific research themes:

Understanding how new blood vessels form to feed tumors – and finding ways to block these processes

Identifying molecules involved in communication between tumor cells and their cellular and structural microenvironment

Uncovering how inflammation triggers and promotes cancer

Integrating knowledge about host-tumor interactions to understand how tumors evolve in a changing microenvironment

Meet the Program Members

The Host-Tumor Interactions program is co-led by Mary M. Zutter, M.D., and Jeffrey Rathmell, Ph.D. The basic, translational, and clinical scientists who make up this program are focused on discovering and understanding these interactions, with the ultimate goal of developing strategies to control tumor progression and metastasis by targeting these interactions.


Featured Publications

Program News

February 4, 2019

Grant supports novel imaging initiative to enhance cancer care

A Vanderbilt initiative to develop predictive imaging technologies that clinicians can use to better match patients with personalized care has received National Cancer Institute (NCI) funding.
January 18, 2019

Research team documents potential new treatment path for breast cancer

Immunotherapies that take off the “brakes” on the adaptive anti-tumor response have worked well in melanoma and lung cancer but less so in breast cancers. That could change.
December 14, 2018

RNA processing and antiviral immunity

A recent study in Nature Communications defines the in vivo substrates of RIG-I like receptors (RLRs) during an oncogenic virus infection and reveals a relationship between cellular RNA processing and an innate antiviral immune response.

Seminars & Events

HT-Events

19 February 2019