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Translational Research and Interventional Oncology Research Program

The Translational Research and Interventional Oncology Research Program  is an integrated multi-disciplinary program that provides the opportunity for clinical investigators and laboratory scientists to collaboratively address the rapidly changing landscape of cancer therapy. The program traverses multiple disciplines, including precision oncology, immuno-oncology, cellular therapy, and immune-toxicity.

RESEARCH THEMES

The Translational Research and Interventional Oncology program is dedicated to translating our understanding of the molecular mechanisms of oncogenesis and tumor progression into novel therapeutic strategies for patients with cancer. 

Developing early phase clinical trials for therapies directed at genetic changes in tumors and for novel immunotherapeutic combinations

Investigating why some tumors become resistant to immunotherapies and genetically targeted therapies and developing new strategies to prevent and overcome resistance

Applying and enhancing innovative immunotherapeutic strategies and cellular therapies for cancer

Meet the Program Members

The Translational Research and Interventional Oncology Program is the largest of the cancer center's formal research programs, representing a range of clinical and translational cancer research areas. The program is led by Douglas Johnson, M.D., M.S.C.I. and Christine M. Lovly, M.D., Ph.D.

Program Leader

Douglas Johnson, M.D., M.S.C.I.

Program Leader

Christine M. Lovly, M.D., Ph.D.
All Program Members

Featured Publications

Featured Publications

Abatacept for severe immune checkpoint inhibitor-associated myocarditis.

Salem, J.E., Allenbach, Y., Vozy, A., Brechot, N., Johnson, D.B. (TR), Moslehi, J.J. (TR) & Kerneis, M.

N Engl J Med 380(24):2377-2379, 2019; PMID:31189043.

View Abstract

Nivolumab Versus Docetaxel in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer: Two-Year Outcomes From Two Randomized, Open-Label, Phase III Trials (CheckMate 017 and CheckMate 057)

Horn L (TR), Spigel DR, Vokes EE, Holgado E, Ready N, Steins M, Poddubskaya E, Borghaei H, Felip E, Paz-Ares L, Pluzanski A, Reckamp KL, Burgio MA, Kohlhäeufl M, Waterhouse D, Barlesi F, Antonia S, Arrieta O, Fayette J, Crinò L, Rizvi N, Reck M, Hellmann MD, Geese WJ, Li A, Blackwood-Chirchir A, Healey D, Brahmer J, Eberhardt WEE

J. Clin. Oncol. 2017 DEC 10 35(35):3924-3933 PMID:29023213

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Phase I/II Trial of Labetuzumab Govitecan (Anti-CEACAM5/SN-38 Antibody-Drug Conjugate) in Patients With Refractory or Relapsing Metastatic Colorectal Cancer

Dotan E, Cohen SJ, Starodub AN, Lieu CH, Messersmith WA, Simpson PS, Guarino MJ, Marshall JL, Goldberg RM, Hecht JR, Wegener WA, Sharkey RM, Govindan SV, Goldenberg DM, Berlin JD (GI, TR)

J. Clin. Oncol. 2017 OCT 10 35(29):3338-3346 PMID:28817371

View Abstract

Myocarditis with Immune Checkpoint Blockade

Moslehi JJ (TR), Johnson DB (TR), Sosman JA. 

N. Engl. J. Med. 2017 JAN 19 376(3):292 PMID:28099832

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Fulminant Myocarditis with Combination Immune Checkpoint Blockade.

Johnson DB (TR), Balko JM (BC), Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, Becker JR, Slosky D (TR), Phillips EJ, Pilkinton MA, Craig-Owens L, Kola N, Plautz G, Reshef DS, Deutsch JS, Deering RP, Olenchock BA, Lichtman AH, Roden DM (NP), Seidman CE, Koralnik IJ, Seidman JG, Hoffman RD, Taube JM, Diaz LA, Anders RA, Sosman JA, Moslehi JJ (TR).

N. Engl. J. Med. 2016 NOV 3 375(18):1749-1755 PMC5247797

View Abstract

Cardiovascular Toxic Effects of Targeted Cancer Therapies.

Moslehi JJ (TR).

N. Engl. J. Med. 2016 OCT 13 375(15):1457-1467 PMID:27732808

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Cracking the Code of Resistance across Multiple Lines of ALK Inhibitor Therapy in Lung Cancer.

Qiao H, Lovly CM (TR).

Cancer Discov 2016 OCT 6(10):1084-1086 PMC5117458.

View Abstract
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Program News

February 5, 2021

Convalescent plasma improved survival in COVID-19 patients with blood cancers

Treatment with convalescent plasma vastly improved the survival rate of patients hospitalized for COVID-19 who also had hematologic malignances that compromise the immune system, according to new data released by the COVID-19 and Cancer Consortium (CCC19).
January 5, 2021

VUMC, Case Western apply artificial intelligence to “customize” oral cancer treatment

Researchers at Vanderbilt University Medical Center and Case Western Reserve University in Cleveland have been awarded a five-year, $3.3 million grant by the National Cancer Institute to apply artificial intelligence (AI) to help customize treatment for oral cancer patients.
October 29, 2020

Lovly to chair foundation’s scientific leadership board

Christine Lovly, MD, PhD, Ingram Associate Professor of Cancer Research, has been named incoming chair of GO2 Foundation’s Scientific Leadership Board (SLB).
More Program News

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NCI Designated Cancer Center
NCCN National Comprehensive Cancer Network
NCI National Clinical Trials Network
CEO Cancer Gold Standard