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A Safety Study of SEA-TGT (SGN-TGT) in Advanced Cancer

Multiple Cancer Types

This trial will look at a drug called SEA-TGT (also known as SGN-TGT) to find out whether it
is safe for patients with solid tumors and lymphomas. It will study SEA-TGT to find out what
its side effects are. A side effect is anything the drug does besides treating cancer. It
will also study whether SEA-TGT works to treat solid tumors and lymphomas.

The study will have three parts. Part A of the study will find out how much SEA-TGT should be
given to patients. Part B will use the dose found in Part A to find out how safe SEA-TGT is
and if it works to treat solid tumors and lymphomas. Part C will study how well SEA-TGT with
sasanlimab works to treat solid tumors.
Gastric/Gastroesophageal, Head/Neck, Lung, Non Small Cell, Ovarian, Phase I
Crispens, Marta