Imaging Biomarkers of Lymphatic Dysfunction
Imaging Biomarkers of Lymphatic Dysfunction
Persons with secondary arm and/or upper quadrant lymphedema following cancer therapies commonly are prescribed complete decongestive therapy as a course of management of their lymphedema. The investigators will perform a repeated-measures cross-over trial to test the hypothesis that mobilization of protein enriched hardened tissue using graded negative pressure therapy in conjunction with complete decongestive therapy (CDT) is more effective to standard CDT alone for secondary lymphedema management.
Breast
N/A
Adults
Not Available
Not Available
Donahue, Manus
Local
Vanderbilt University
11-20-2018
Eligibility
30 Years to 90 Years
FEMALE
false
Inclusion Criteria:
Females with a diagnosis of secondary arm and/or upper quadrant lymphedema following cancer treatments
Females with a diagnosis of secondary arm and/or upper quadrant lymphedema following cancer treatments
Exclusion Criteria:
Subjects who have any type of non-MRI compatible bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps, etc.) or are not able to comfortably be able to tolerate the limited fit of the MRI
Subjects who have any type of non-MRI compatible bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps, etc.) or are not able to comfortably be able to tolerate the limited fit of the MRI
Subjects who have any type of ferromagnetic bioimplant that could potentially be displaced.
Subjects who have any type of ferromagnetic bioimplant that could potentially be displaced.
Subjects who may have shrapnel embedded in their bodies (such as from war wounds), metal workers and machinists (potential for metallic fragments in or near the eyes).
Subjects who may have shrapnel embedded in their bodies (such as from war wounds), metal workers and machinists (potential for metallic fragments in or near the eyes).
Pregnant women will be excluded from the MRI portion of the study only
Pregnant women will be excluded from the MRI portion of the study only
Subjects who have open wounds on either ankle or top of foot because of contraindications with placement of electrodes to obtain the L-DEX U400 readings.
Subjects who have open wounds on either ankle or top of foot because of contraindications with placement of electrodes to obtain the L-DEX U400 readings.
Persons with heart pacemakers.
Persons with heart pacemakers.
Persons with bilateral arm lymphedema (or bilateral risk) or pre-existing lymphedema/edema in the upper body prior to cancer treatments.
Persons with bilateral arm lymphedema (or bilateral risk) or pre-existing lymphedema/edema in the upper body prior to cancer treatments.
Females with a diagnosis of secondary arm and/or upper quadrant lymphedema following cancer treatments
Females with a diagnosis of secondary arm and/or upper quadrant lymphedema following cancer treatments
Exclusion Criteria:
Subjects who have any type of non-MRI compatible bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps, etc.) or are not able to comfortably be able to tolerate the limited fit of the MRI
Subjects who have any type of non-MRI compatible bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps, etc.) or are not able to comfortably be able to tolerate the limited fit of the MRI
Subjects who have any type of ferromagnetic bioimplant that could potentially be displaced.
Subjects who have any type of ferromagnetic bioimplant that could potentially be displaced.
Subjects who may have shrapnel embedded in their bodies (such as from war wounds), metal workers and machinists (potential for metallic fragments in or near the eyes).
Subjects who may have shrapnel embedded in their bodies (such as from war wounds), metal workers and machinists (potential for metallic fragments in or near the eyes).
Pregnant women will be excluded from the MRI portion of the study only
Pregnant women will be excluded from the MRI portion of the study only
Subjects who have open wounds on either ankle or top of foot because of contraindications with placement of electrodes to obtain the L-DEX U400 readings.
Subjects who have open wounds on either ankle or top of foot because of contraindications with placement of electrodes to obtain the L-DEX U400 readings.
Persons with heart pacemakers.
Persons with heart pacemakers.
Persons with bilateral arm lymphedema (or bilateral risk) or pre-existing lymphedema/edema in the upper body prior to cancer treatments.
Persons with bilateral arm lymphedema (or bilateral risk) or pre-existing lymphedema/edema in the upper body prior to cancer treatments.
