Julie Ann Rhoades (Sterling), Ph.D.
- Associate Professor of Medicine (Clinical Pharmacology )
- Associate Professor of Biomedical Engineering
- Ph.D., Medical College of Ohio, Toledo, Ohio (2003)
- B.S., Bowling Green State University, Bowling Green, Ohio (1998)
Cancer metastasis to bone and tumor-induced bone disease.
Our research focuses tumors (including breast, prostate, lung, myeloma, oral cancer, and others) that metastasize or invade into the bone and induce subsequent changes in the bone that lead to increased fracture rates and pain in patients. Unfortunately, there are no cures for tumors once they have established in bone. We study the mechanisms that regulate tumor establishment in bone and bone destruction, which requires a blend of molecular biology, engineering, and pre-clinical models. These techniques together have helped us better understand tumor-induced bone disease and have allowed us to begin testing promising therapeutics in small animal models of tumor-induced bone disease.
Specifically, our previous studies have demonstrated that the expression of Gli2, a transcription factor, is strongly correlated with tumor cells that induce bone destruction. We have further shown that the physical and cellular components of the bone and bone marrow can alter gene expression and tumor behavior. Our current work is further exploring how complex interactions with the bone/bone marrow contribute to disease, and have begun testing inhibitor of signaling pathways important for tumor interactions with the bone microenvironment.
- Kwakwa KA, Vanderburgh JP, Guelcher SA, Sterling JA. Engineering 3D Models of Tumors and Bone to Understand Tumor-Induced Bone Disease and Improve Treatments. Curr Osteoporos Rep. 2017 Aug; 15(4): 247-54. PMID: 28646444, PII: 10.1007/s11914-017-0385-9, DOI: 10.1007/s11914-017-0385-9, ISSN: 1544-2241.
- Kwakwa KA, Sterling JA. Integrin avß3 Signaling in Tumor-Induced Bone Disease. Cancers (Basel). 2017 Jul 7/8/2017; 9(7): PMID: 28698458, PMCID: PMC5532620, PII: cancers9070084, DOI: 10.3390/cancers9070084, ISSN: 2072-6694.
- Mulcrone PL, Campbell JP, Clément-Demange L, Anbinder AL, Merkel AR, Brekken RA, Sterling JA, Elefteriou F. Skeletal Colonization by Breast Cancer Cells Is Stimulated by an Osteoblast and ß2AR-Dependent Neo-Angiogenic Switch. J. Bone Miner. Res [print-electronic]. 2017 Jul; 32(7): 1442-54. PMID: 28300321, PMCID: PMC5489363, DOI: 10.1002/jbmr.3133, ISSN: 1523-4681.
- Cannonier SA, Gonzales CB, Ely K, Guelcher SA, Sterling JA. Hedgehog and TGFß signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma. Oncotarget [print-electronic]. 2016 Oct 10/12/2016; PMID: 27738315, PII: 12584, DOI: 10.18632/oncotarget.12584, ISSN: 1949-2553.
- Johnson RW, Finger EC, Olcina MM, Vilalta M, Aguilera T, Miao Y, Merkel AR, Johnson JR, Sterling JA, Wu JY, Giaccia AJ. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat. Cell Biol [print-electronic]. 2016 Sep 9/19/2016; 18(10): 1078-89. PMID: 27642788, PII: ncb3408, DOI: 10.1038/ncb3408, ISSN: 1476-4679.
- Buenrostro D, Mulcrone PL, Owens P, Sterling JA. The Bone Microenvironment: a Fertile Soil for Tumor Growth. Curr Osteoporos Rep. 2016 Aug; 14(4): 151-8. PMID: 27255469, PMCID: PMC4927340, PII: 10.1007/s11914-016-0315-2, DOI: 10.1007/s11914-016-0315-2, ISSN: 1544-2241.
- Nyman JS, Merkel AR, Uppuganti S, Nayak B, Rowland B, Makowski AJ, Oyajobi BO, Sterling JA. Combined treatment with a transforming growth factor beta inhibitor (1D11) and bortezomib improves bone architecture in a mouse model of myeloma-induced bone disease. Bone [print-electronic]. 2016 Jul 7/13/2016; PMID: 27423464, PII: S8756-3282(16)30187-9, DOI: 10.1016/j.bone.2016.07.007, ISSN: 1873-2763.
- Guo R, Lu S, Merkel AR, Sterling JA, Guelcher SA. Substrate Modulus Regulates Osteogenic Differentiation of Rat Mesenchymal Stem Cells through Integrin ß1 and BMP Receptor Type IA. J Mater Chem B Mater Biol Med [print-electronic]. 2016 May 5/28/2016; 4(20): 3584-93. PMID: 27551426, PMCID: PMC4991780, DOI: 10.1039/C5TB02747K, ISSN: 2050-750X.
- Vanderburgh J, Sterling JA, Guelcher SA. 3D Printing of Tissue Engineered Constructs for In Vitro Modeling of Disease Progression and Drug Screening. Ann Biomed Eng [print-electronic]. 2016 May 5/11/2016; PMID: 27169894, PII: 10.1007/s10439-016-1640-4, DOI: 10.1007/s10439-016-1640-4, ISSN: 1573-9686.
- Wright LE, Ottewell PD, Rucci N, Peyruchaud O, Pagnotti GM, Chiechi A, Buijs JT, Sterling JA. Murine models of breast cancer bone metastasis. Bonekey Rep. 2016; 5: 804. PMID: 27867497, PMCID: PMC5108088, DOI: 10.1038/bonekey.2016.31, ISSN: 2047-6396.