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Melinda Aldrich, Ph.D., M.P.H.

  • Assistant Professor of Thoracic Surgery

Phone

(615) 322-3386

Email

melinda.aldrich@Vanderbilt.Edu
609 Oxford House
1313 21st Ave. South
Nashville, TN 37232-4682

Melinda Aldrich, Ph.D., M.P.H.

  • Assistant Professor of Thoracic Surgery

(615) 322-3386

melinda.aldrich@Vanderbilt.Edu

609 Oxford House
1313 21st Ave. South
Nashville, TN 37232-4682

Profile

Melinda Aldrich is an Assistant Professor in the Vanderbilt University School of Medicine. Her research focuses on identifying genetic and environmental factors contributing to health disparities in lung cancer incidence and survival. Dr. Aldrich's interests also include personalized genomic testing and pharmacogenetics.

Education

  • Ph.D., University of California, Berkeley (2007)
  • M.P.H., University of California, Berkeley (2003)
  • B.A., University of California, Santa Cruz (1992)

Research Emphasis

Genetic epidemiology, Racially diverse populations, Lung cancer, Pulmonary disease, Health disparities, Social and environmental factors, DNA biobanks

Research Description

Our research is focused on understanding why there are differences in lung cancer risk and survival among different racial/ethnic populations. Specifically, my lab is focused on identifying genetic, social and environmental risk factors for lung cancer and its related phenotypes, such as nicotine addiction and pulmonary function. Investigating gene-environment and gene-gene interactions may explain some of the differences in disease between racial/ethnic groups.

African Americans have the highest lung cancer incidence and mortality compared to all other racial/ethnic groups. We use large-scale cohorts such as the Southern Community Cohort Study (SCCS) to understand genetic and environmental factors contributing to disease in racially mixed populations. This research includes collecting genetic, clinical, biomarker and environmental data and then combining these data to understand lung cancer prognosis. Additional ongoing projects are using the Vanderbilt electronic health records linked to the DNA databank (BioVU) to explore genetic contributors to chronic obstructive pulmonary disease (COPD).

Publications

  • Jones CC, Bush WS, Crawford DC, Wenzlaff AS, Schwartz AG, Wiencke JK, Wrensch MR, Blot WJ, Chanock SJ, Grogan EL, Aldrich MC. Germline Genetic Variants and Lung Cancer Survival in African Americans. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2017 Aug; 26(8): 1288-95. PMID: 28619829, PMCID: PMC5540773, PII: 1055-9965.EPI-16-0998, DOI: 10.1158/1055-9965.EPI-16-0998, ISSN: 1538-7755.
  • McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, Liu G, Timofeeva MN, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman CA, Wilkens LR, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden HFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty JA, Barnett MP, Chen C, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Wichmann HE, Manz J, Muley TR, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd FA, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston RS, McLaughlin J, Stevens VL, Joubert P, Lamontagne M, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Kachuri L, Artigas MS, Tobin MD, Wain LV, , Rafnar T, Thorgeirsson TE, Reginsson GW, Stefansson K, Hancock DB, Bierut LJ, Spitz MR, Gaddis NC, Lutz SM, Gu F, Johnson EO, Kamal A, Pikielny C, Zhu D, Lindströem S, Jiang X, Tyndale RF, Chenevix-Trench G, Beesley J, Bossé Y, Chanock S, Brennan P, Landi MT, Amos CI. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Nat. Genet [print-electronic]. 2017 Jul; 49(7): 1126-32. PMID: 28604730, PMCID: PMC5510465, PII: ng.3892, DOI: 10.1038/ng.3892, ISSN: 1546-1718.
  • Kodaman N, Sobota RS, Asselbergs FW, Oetjens MT, Moore JH, Brown NJ, Aldrich MC, Williams SM. Genetic Effects on the Correlation Structure of CVD Risk Factors: Exome-Wide Data From a Ghanaian Population. Glob Heart [print-electronic]. 2017 Apr 4/10/2017; PMID: 28408189, PII: S2211-8160(17)30013-3, DOI: 10.1016/j.gheart.2017.01.013, ISSN: 2211-8179.
  • Ciesielski TH, Aldrich MC, Marsit CJ, Hiatt RA, Williams SM. Transdisciplinary approaches enhance the production of translational knowledge. Transl Res [print-electronic]. 2017 Apr; 182: 123-34. PMID: 27893987, PMCID: PMC5362296, PII: S1931-5244(16)30353-X, DOI: 10.1016/j.trsl.2016.11.002, ISSN: 1878-1810.
  • Sausville LN, Jones CC, Aldrich MC, Blot WJ, Pozzi A, Williams SM. Genetic variation in the eicosanoid pathway is associated with non-small-cell lung cancer (NSCLC) survival. PLoS ONE. 2017; 12(7): e0180471. PMID: 28704416, PMCID: PMC5509150, PII: PONE-D-17-07758, DOI: 10.1371/journal.pone.0180471, ISSN: 1932-6203.
  • Giri A, Hartmann KE, Aldrich MC, Ward RM, Wu JM, Park AJ, Graff M, Qi L, Nassir R, Wallace RB, O'Sullivan MJ, North KE, Velez Edwards DR, Edwards TL. Admixture mapping of pelvic organ prolapse in African Americans from the Women's Health Initiative Hormone Therapy trial. PLoS ONE. 2017; 12(6): e0178839. PMID: 28582460, PMCID: PMC5459562, PII: PONE-D-16-33760, DOI: 10.1371/journal.pone.0178839, ISSN: 1932-6203.
  • Carreras-Torres R, Johansson M, Haycock PC, Wade KH, Relton CL, Martin RM, Davey Smith G, Albanes D, Aldrich MC, Andrew A, Arnold SM, Bickeböller H, Bojesen SE, Brunnström H, Manjer J, Brüske I, Caporaso NE, Chen C, Christiani DC, Christian WJ, Doherty JA, Duell EJ, Field JK, Davies MPA, Marcus MW, Goodman GE, Grankvist K, Haugen A, Hong YC, Kiemeney LA, van der Heijden EHFM, Kraft P, Johansson MB, Lam S, Landi MT, Lazarus P, Le Marchand L, Liu G, Melander O, Park SL, Rennert G, Risch A, Haura EB, Scelo G, Zaridze D, Mukeriya A, Savic M, Lissowska J, Swiatkowska B, Janout V, Holcatova I, Mates D, Schabath MB, Shen H, Tardon A, Teare MD, Woll P, Tsao MS, Wu X, Yuan JM, Hung RJ, Amos CI, McKay J, Brennan P. Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study. PLoS ONE. 2017; 12(6): e0177875. PMID: 28594918, PMCID: PMC5464539, PII: PONE-D-17-10050, DOI: 10.1371/journal.pone.0177875, ISSN: 1932-6203.
  • Kodaman N, Aldrich MC, Sobota R, Asselbergs FW, Brown NJ, Moore JH, Williams SM. Plasminogen Activator Inhibitor-1 and Diagnosis of the Metabolic Syndrome in a West African Population. J Am Heart Assoc. 2016 Oct 10/3/2016; 5(10): PMID: 27697752, PMCID: PMC5121488, PII: JAHA.116.003867, DOI: 10.1161/JAHA.116.003867, ISSN: 2047-9980.
  • Zanetti KA, Wang Z, Aldrich M, Amos CI, Blot WJ, Bowman ED, Burdette L, Cai Q, Caporaso N, Chung CC, Gillanders EM, Haiman CA, Hansen HM, Henderson BE, Kolonel LN, Marchand LL, Li S, McNeill LH, Ryan BM, Schwartz AG, Sison JD, Spitz MR, Tucker M, Wenzlaff AS, Wiencke JK, Wilkens L, Wrensch MR, Wu X, Zheng W, Zhou W, Christiani D, Palmer JR, Penning TM, Rieber AG, Rosenberg L, Ruiz-Narvaez EA, Su L, Vachani A, Wei Y, Whitehead AS, Chanock SJ, Harris CC. Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Lung Cancer [print-electronic]. 2016 Aug; 98: 33-42. PMID: 27393504, PMCID: PMC4939239, PII: S0169-5002(16)30320-8, DOI: 10.1016/j.lungcan.2016.05.008, ISSN: 1872-8332.
  • Machiela MJ, Zhou W, Karlins E, Sampson JN, Freedman ND, Yang Q, Hicks B, Dagnall C, Hautman C, Jacobs KB, Abnet CC, Aldrich MC, Amos C, Amundadottir LT, Arslan AA, Beane-Freeman LE, Berndt SI, Black A, Blot WJ, Bock CH, Bracci PM, Brinton LA, Bueno-de-Mesquita HB, Burdett L, Buring JE, Butler MA, Canzian F, Carreón T, Chaffee KG, Chang IS, Chatterjee N, Chen C, Chen C, Chen K, Chung CC, Cook LS, Crous Bou M, Cullen M, Davis FG, De Vivo I, Ding T, Doherty J, Duell EJ, Epstein CG, Fan JH, Figueroa JD, Fraumeni JF, Friedenreich CM, Fuchs CS, Gallinger S, Gao YT, Gapstur SM, Garcia-Closas M, Gaudet MM, Gaziano JM, Giles GG, Gillanders EM, Giovannucci EL, Goldin L, Goldstein AM, Haiman CA, Hallmans G, Hankinson SE, Harris CC, Henriksson R, Holly EA, Hong YC, Hoover RN, Hsiung CA, Hu N, Hu W, Hunter DJ, Hutchinson A, Jenab M, Johansen C, Khaw KT, Kim HN, Kim YH, Kim YT, Klein AP, Klein R, Koh WP, Kolonel LN, Kooperberg C, Kraft P, Krogh V, Kurtz RC, LaCroix A, Lan Q, Landi MT, Marchand LL, Li D, Liang X, Liao LM, Lin D, Liu J, Lissowska J, Lu L, Magliocco AM, Malats N, Matsuo K, McNeill LH, McWilliams RR, Melin BS, Mirabello L, Moore L, Olson SH, Orlow I, Park JY, Patiño-Garcia A, Peplonska B, Peters U, Petersen GM, Pooler L, Prescott J, Prokunina-Olsson L, Purdue MP, Qiao YL, Rajaraman P, Real FX, Riboli E, Risch HA, Rodriguez-Santiago B, Ruder AM, Savage SA, Schumacher F, Schwartz AG, Schwartz KL, Seow A, Wendy Setiawan V, Severi G, Shen H, Sheng X, Shin MH, Shu XO, Silverman DT, Spitz MR, Stevens VL, Stolzenberg-Solomon R, Stram D, Tang ZZ, Taylor PR, Teras LR, Tobias GS, Van Den Berg D, Visvanathan K, Wacholder S, Wang JC, Wang Z, Wentzensen N, Wheeler W, White E, Wiencke JK, Wolpin BM, Wong MP, Wu C, Wu T, Wu X, Wu YL, Wunder JS, Xia L, Yang HP, Yang PC, Yu K, Zanetti KA, Zeleniuch-Jacquotte A, Zheng W, Zhou B, Ziegler RG, Perez-Jurado LA, Caporaso NE, Rothman N, Tucker M, Dean MC, Yeager M, Chanock SJ. Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome. Nat Commun. 2016 Jun 6/13/2016; 7: 11843. PMID: 27291797, PMCID: PMC4909985, PII: ncomms11843, DOI: 10.1038/ncomms11843, ISSN: 2041-1723.
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