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Melinda Aldrich, Ph.D., M.P.H.

  • Assistant Professor of Thoracic Surgery
  • Assistant Professor of Medicine
  • Assistant Professor of Biomedical Informatics

Phone

(615) 322-3386

Email

melinda.aldrich@Vanderbilt.Edu
609 Oxford House
1313 21st Ave. South
Nashville, TN 37232-4682

Melinda Aldrich, Ph.D., M.P.H.

  • Assistant Professor of Thoracic Surgery
  • Assistant Professor of Medicine
  • Assistant Professor of Biomedical Informatics

(615) 322-3386

melinda.aldrich@Vanderbilt.Edu

609 Oxford House
1313 21st Ave. South
Nashville, TN 37232-4682

Profile

Melinda Aldrich is an Assistant Professor in the Vanderbilt University School of Medicine. Her research focuses on identifying genetic and environmental factors contributing to health disparities in lung cancer incidence and survival. Dr. Aldrich's interests also include personalized genomic testing and pharmacogenetics.

Education

  • Ph.D., University of California, Berkeley (2007)
  • M.P.H., University of California, Berkeley (2003)
  • B.A., University of California, Santa Cruz (1992)

Research Emphasis

Genetic epidemiology, Racially diverse populations, Lung cancer, Pulmonary disease, Health disparities, Social and environmental factors, DNA biobanks

Research Description

Our research is focused on understanding why there are differences in lung cancer risk and survival among different racial/ethnic populations. Specifically, my lab is focused on identifying genetic, social and environmental risk factors for lung cancer and its related phenotypes, such as nicotine addiction and pulmonary function. Investigating gene-environment and gene-gene interactions may explain some of the differences in disease between racial/ethnic groups.

African Americans have the highest lung cancer incidence and mortality compared to all other racial/ethnic groups. We use large-scale cohorts such as the Southern Community Cohort Study (SCCS) to understand genetic and environmental factors contributing to disease in racially mixed populations. This research includes collecting genetic, clinical, biomarker and environmental data and then combining these data to understand lung cancer prognosis. Additional ongoing projects are using the Vanderbilt electronic health records linked to the DNA databank (BioVU) to explore genetic contributors to chronic obstructive pulmonary disease (COPD).

Publications

  • Rosenberger A, Hung RJ, Christiani DC, Caporaso NE, Liu G, Bojesen SE, Le Marchand L, Haiman CA, Albanes D, Aldrich MC, Tardon A, Fernández-Tardón G, Rennert G, Field JK, Kiemeney B, Lazarus P, Haugen A, Zienolddiny S, Lam S, Schabath MB, Andrew AS, Brunnsstöm H, Goodman GE, Doherty JA, Chen C, Teare MD, Wichmann HE, Manz J, Risch A, Muley TR, Johansson M, Brennan P, Landi MT, Amos CI, Pesch B, Johnen G, Brüning T, Bickeböller H, Gomolka M. Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners. Int Arch Occup Environ Health [print-electronic]. 2018 Nov; 91(8): 937-50. PMID: 29971594, PII: 10.1007/s00420-018-1334-3, DOI: 10.1007/s00420-018-1334-3, ISSN: 1432-1246.
  • Jones CC, Mercaldo SF, Blume JD, Wenzlaff AS, Schwartz AG, Chen H, Deppen SA, Bush WS, Crawford DC, Chanock SJ, Blot WJ, Grogan EL, Aldrich MC. Racial Disparities in Lung Cancer Survival: The Contribution of Stage, Treatment, and Ancestry. J Thorac Oncol [print-electronic]. 2018 Oct; 13(10): 1464-73. PMID: 29885480, PMCID: PMC6153049, PII: S1556-0864(18)30682-8, DOI: 10.1016/j.jtho.2018.05.032, ISSN: 1556-1380.
  • Ferreiro-Iglesias A, Lesseur C, McKay J, Hung RJ, Han Y, Zong X, Christiani D, Johansson M, Xiao X, Li Y, Qian DC, Ji X, Liu G, Caporaso N, Scelo G, Zaridze D, Mukeriya A, Kontic M, Ognjanovic S, Lissowska J, Szolkowska M, Swiatkowska B, Janout V, Holcatova I, Bolca C, Savic M, Ognjanovic M, Bojesen SE, Wu X, Albanes D, Aldrich MC, Tardon A, Fernandez-Somoano A, Fernandez-Tardon G, Le Marchand L, Rennert G, Chen C, Doherty J, Goodman G, Bickeböller H, Wichmann HE, Risch A, Rosenberger A, Shen H, Dai J, Field JK, Davies M, Woll P, Teare MD, Kiemeney LA, van der Heijden EHFM, Yuan JM, Hong YC, Haugen A, Zienolddiny S, Lam S, Tsao MS, Johansson M, Grankvist K, Schabath MB, Andrew A, Duell E, Melander O, Brunnström H, Lazarus P, Arnold S, Slone S, Byun J, Kamal A, Zhu D, Landi MT, Amos CI, Brennan P. Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity. Nat Commun. 2018 Sep 9/25/2018; 9(1): 3927. PMID: 30254314, PMCID: PMC6156406, PII: 10.1038/s41467-018-05890-2, DOI: 10.1038/s41467-018-05890-2, ISSN: 2041-1723.
  • Sanderson M, Aldrich MC, Levine RS, Kilbourne B, Cai Q, Blot WJ. Neighbourhood deprivation and lung cancer risk: a nested case-control study in the USA. BMJ Open. 2018 Sep 9/10/2018; 8(9): e021059. PMID: 30206077, PMCID: PMC6144393, PII: bmjopen-2017-021059, DOI: 10.1136/bmjopen-2017-021059, ISSN: 2044-6055.
  • Ji X, Bossé Y, Landi MT, Gui J, Xiao X, Qian D, Joubert P, Lamontagne M, Li Y, Gorlov I, de Biasi M, Han Y, Gorlova O, Hung RJ, Wu X, McKay J, Zong X, Carreras-Torres R, Christiani DC, Caporaso N, Johansson M, Liu G, Bojesen SE, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Chen C, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman C, Wilkens L, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden EHFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty J, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Manz J, Muley T, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd F, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston R, McLaughlin J, Stevens V, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Artigas MS, Tobin MD, Wain LV, Gu F, Byun J, Kamal A, Zhu D, Tyndale RF, Wei WQ, Chanock S, Brennan P, Amos CI. Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. Nat Commun. 2018 Aug 8/13/2018; 9(1): 3221. PMID: 30104567, PMCID: PMC6089967, PII: 10.1038/s41467-018-05074-y, DOI: 10.1038/s41467-018-05074-y, ISSN: 2041-1723.
  • Kachuri L, Saarela O, Bojesen SE, Davey Smith G, Liu G, Landi MT, Caporaso NE, Christiani DC, Johansson M, Panico S, Overvad K, Trichopoulou A, Vineis P, Scelo G, Zaridze D, Wu X, Albanes D, Diergaarde B, Lagiou P, Macfarlane GJ, Aldrich MC, Tardón A, Rennert G, Olshan AF, Weissler MC, Chen C, Goodman GE, Doherty JA, Ness AR, Bickeböller H, Wichmann HE, Risch A, Field JK, Teare MD, Kiemeney LA, van der Heijden EHFM, Carroll JC, Haugen A, Zienolddiny S, Skaug V, Wünsch-Filho V, Tajara EH, Ayoub Moysés R, Daumas Nunes F, Lam S, Eluf-Neto J, Lacko M, Peters WHM, Le Marchand L, Duell EJ, Andrew AS, Franceschi S, Schabath MB, Manjer J, Arnold S, Lazarus P, Mukeriya A, Swiatkowska B, Janout V, Holcatova I, Stojsic J, Mates D, Lissowska J, Boccia S, Lesseur C, Zong X, McKay JD, Brennan P, Amos CI, Hung RJ. Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers. Int J Epidemiol [print-electronic]. 2018 Jul 7/28/2018; PMID: 30059977, PII: 5061128, DOI: 10.1093/ije/dyy140, ISSN: 1464-3685.
  • Ji X, Niu X, Qian J, Martucci V, Pendergrass SA, Gorlov IP, Amos CI, Denny JC, Massion PP, Aldrich MC. A Phenome-Wide Association Study Uncovers a Role for Autoimmunity in the Development of Chronic Obstructive Pulmonary Disease. Am. J. Respir. Cell Mol. Biol. 2018 Jun; 58(6): 777-9. PMID: 29856256, PMCID: PMC6002656, DOI: 10.1165/rcmb.2017-0409LE, ISSN: 1535-4989.
  • Li Y, Xiao X, Han Y, Gorlova O, Qian D, Leighl N, Johansen JS, Barnett M, Chen C, Goodman G, Cox A, Taylor F, Woll P, Wichmann HE, Manz J, Muley T, Risch A, Rosenberger A, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Houlston R, Soler Artigas M, Grankvist K, Johansson M, Shepherd FA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Liu G, Bojesen SE, Wu X, Marchand LL, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Bertazzi PA, Pesatori AC, Christiani DC, Caporaso N, Johansson M, McKay JD, Brennan P, Hung RJ, Amos CI. Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population. Carcinogenesis. 2018 Mar 3/8/2018; 39(3): 336-46. PMID: 29059373, PMCID: PMC6248554, PII: 4558711, DOI: 10.1093/carcin/bgx113, ISSN: 1460-2180.
  • Conti DV, Wang K, Sheng X, Bensen JT, Hazelett DJ, Cook MB, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B, Isaacs WB, Stanford JL, Zheng W, Sanderson M, John EM, Park JY, Xu J, Stevens VL, Berndt SI, Huff CD, Wang Z, Yeboah ED, Tettey Y, Biritwum RB, Adjei AA, Tay E, Truelove A, Niwa S, Sellers TA, Yamoah K, Murphy AB, Crawford DC, Gapstur SM, Bush WS, Aldrich MC, Cussenot O, Petrovics G, Cullen J, Neslund-Dudas C, Stern MC, Jarai ZK, Govindasami K, Chokkalingam AP, Hsing AW, Goodman PJ, Hoffmann T, Drake BF, Hu JJ, Clark PE, Van Den Eeden SK, Blanchet P, Fowke JH, Casey G, Hennis AJM, Han Y, Lubwama A, Thompson IM, Leach R, Easton DF, Schumacher F, Van den Berg DJ, Gundell SM, Stram A, Wan P, Xia L, Pooler LC, Mohler JL, Fontham ETH, Smith GJ, Taylor JA, Srivastava S, Eeles RA, Carpten J, Kibel AS, Multigner L, Parent ME, Menegaux F, Cancel-Tassin G, Klein EA, Brureau L, Stram DO, Watya S, Chanock SJ, Witte JS, Blot WJ, Henderson BE, Haiman CA, . Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry. J. Natl. Cancer Inst. 2017 Aug 8/1/2017; 109(8): PMID: 29117387, PMCID: PMC5448553, PII: 3858844, DOI: 10.1093/jnci/djx084, ISSN: 1460-2105.
  • Jones CC, Bush WS, Crawford DC, Wenzlaff AS, Schwartz AG, Wiencke JK, Wrensch MR, Blot WJ, Chanock SJ, Grogan EL, Aldrich MC. Germline Genetic Variants and Lung Cancer Survival in African Americans. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2017 Aug; 26(8): 1288-95. PMID: 28619829, PMCID: PMC5540773, PII: 1055-9965.EPI-16-0998, DOI: 10.1158/1055-9965.EPI-16-0998, ISSN: 1538-7755.
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