
Nancy J. Cox, Ph.D.
- Mary Phillips Edmonds Gray Professor of Genetics
- Professor of Medicine
- Director, Vanderbilt Genetics Institute
- Director, Division of Genetic Medicine
Nancy J. Cox, Ph.D.
- Mary Phillips Edmonds Gray Professor of Genetics
- Professor of Medicine
- Director, Vanderbilt Genetics Institute
- Director, Division of Genetic Medicine
(615) 322-2091
nancy.j.cox@vumc.org
Nashville, TN 37232-0700
Research Program
Departments/Affiliations
Profile
Nancy Cox is a quantitative human geneticist with a long-standing research program focused on identifying and characterizing the genetic component to common human diseases and related traits. Her lab is computational and a major current research activity is in developing methods integrating genome function and genome variation and in applying these new methods to data on common diseases. Dr. Cox has been funded to develop and apply methods for the analysis of sequence data (for the 1000 Genomes Project) and of transcriptome data (for the GTEx -- Genotype Tissue Expression -- project), and to conduct genetic / genomic studies in type 2 diabetes and its complications, pharmacogenomics of anti-cancer agents, breast cancer, mesothelioma, and neuropsychiatric disorders including Tourette Syndrome, obsessive compulsive disorder, autism, bipolar disorder and schizophrenia. A major focus of future research will be applying novel integrative methods for analyzing data in BioVU, the biobank at Vanderbilt University, with DNA samples on more than 215,000 subjects linked to a high-quality electronic health record going back more than 20 years. Due to investments made by Vanderbilt University Medical Center, BioVU will have genome interrogation on more than 120,000 subjects by then end of 2017, permitting unprecedented investigations into how genome variation contributes to the entire medical phenome.
Education
- Ph.D., Yale University, New Haven, Connecticut (1982)
- B.Sc., University of Notre Dame, South Bend, Indiana (1978)
Postgraduate Training
- Post-doctoral fellowship, Washington University (1982-1985)
- Post-doctoral fellowship, University of Pennsylvania (1985-1987)
Research Emphasis
Research Description
Publications
- Morselli LL, Gamazon ER, Tasali E, Cox NJ, Van Cauter E, Davis LK. Shared Genetic Control of Brain Activity During Sleep and Insulin Secretion: A Laboratory-Based Family Study. Diabetes [print-electronic]. 2017 Oct 10/30/2017; PMID: 29084784, PII: db16-1229, DOI: 10.2337/db16-1229, ISSN: 1939-327X.
- Dolan ME, El Charif O, Wheeler HE, Gamazon ER, Ardeshir-Rouhani-Fard S, Monahan P, Feldman DR, Hamilton RJ, Vaughn DJ, Beard CJ, Fung C, Kim J, Fossa SD, Hertz DL, Mushiroda T, Kubo M, Einhorn LH, Cox NJ, Travis LB, . Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer. Clin. Cancer Res [print-electronic]. 2017 Oct 10/1/2017; 23(19): 5757-68. PMID: 28611204, PMCID: PMC5626588, PII: 1078-0432.CCR-16-3224, DOI: 10.1158/1078-0432.CCR-16-3224, ISSN: 1078-0432.
- Mechanic LE, Lindström S, Daily KM, Sieberts SK, Amos CI, Chen HS, Cox NJ, Dathe M, Feuer EJ, Guertin MJ, Hoffman J, Liu Y, Moore JH, Myers CL, Ritchie MD, Schildkraut J, Schumacher F, Witte JS, Wang W, Williams SM, , , Gillanders EM. Up For A Challenge (U4C): Stimulating innovation in breast cancer genetic epidemiology [editorial]. PLoS Genet. 2017 Sep; 13(9): e1006945. PMID: 28957327, PMCID: PMC5619686, PII: PGENETICS-D-17-01043, DOI: 10.1371/journal.pgen.1006945, ISSN: 1553-7404.
- Wang K, Gaitsch H, Poon H, Cox NJ, Rzhetsky A. Classification of common human diseases derived from shared genetic and environmental determinants. Nat. Genet [print-electronic]. 2017 Sep; 49(9): 1319-25. PMID: 28783162, PMCID: PMC5577363, PII: ng.3931, DOI: 10.1038/ng.3931, ISSN: 1546-1718.
- Cox NJ. Reaching for the next branch on the biobank tree of knowledge. Nature genetics. 2017 Aug 8/30/2017; 49(9) Sect. 1295,1296.
- Gamazon ER, Konkashbaev A, Derks EM, Cox NJ, Lee Y. Evidence of selection on splicing-associated loci in human populations and relevance to disease loci mapping. Sci Rep. 2017 Jul 7/20/2017; 7(1): 5980. PMID: 28729732, PMCID: PMC5519721, PII: 10.1038/s41598-017-05744-9, DOI: 10.1038/s41598-017-05744-9, ISSN: 2045-2322.
- Wheeler HE, Gamazon ER, Frisina RD, Perez-Cervantes C, El Charif O, Mapes B, Fossa SD, Feldman DR, Hamilton RJ, Vaughn DJ, Beard CJ, Fung C, Kollmannsberger C, Kim J, Mushiroda T, Kubo M, Ardeshir-Rouhani-Fard S, Einhorn LH, Cox NJ, Dolan ME, Travis LB. Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Clin. Cancer Res [print-electronic]. 2017 Jul 7/1/2017; 23(13): 3325-33. PMID: 28039263, PMCID: PMC5493516, PII: 1078-0432.CCR-16-2809, DOI: 10.1158/1078-0432.CCR-16-2809, ISSN: 1078-0432.
- Huang AY, Yu D, Davis LK, Sul JH, Tsetsos F, Ramensky V, Zelaya I, Ramos EM, Osiecki L, Chen JA, McGrath LM, Illmann C, Sandor P, Barr CL, Grados M, Singer HS, Nöthen MM, Hebebrand J, King RA, Dion Y, Rouleau G, Budman CL, Depienne C, Worbe Y, Hartmann A, Müller-Vahl KR, Stuhrmann M, Aschauer H, Stamenkovic M, Schloegelhofer M, Konstantinidis A, Lyon GJ, McMahon WM, Barta C, Tarnok Z, Nagy P, Batterson JR, Rizzo R, Cath DC, Wolanczyk T, Berlin C, Malaty IA, Okun MS, Woods DW, Rees E, Pato CN, Pato MT, Knowles JA, Posthuma D, Pauls DL, Cox NJ, Neale BM, Freimer NB, Paschou P, Mathews CA, Scharf JM, Coppola G, , . Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome. Neuron. 2017 Jun 6/21/2017; 94(6): 1101-1111.e7. PMID: 28641109, PMCID: PMC5568251, PII: S0896-6273(17)30508-1, DOI: 10.1016/j.neuron.2017.06.010, ISSN: 1097-4199.
- Hohman TJ, Dumitrescu L, Cox NJ, Jefferson AL, . Genetic resilience to amyloid related cognitive decline. Brain Imaging Behav. 2017 Apr; 11(2): 401-9. PMID: 27743375, PMCID: PMC5392179, PII: 10.1007/s11682-016-9615-5, DOI: 10.1007/s11682-016-9615-5, ISSN: 1931-7565.
- Manolio TA, Fowler DM, Starita LM, Haendel MA, MacArthur DG, Biesecker LG, Worthey E, Chisholm RL, Green ED, Jacob HJ, McLeod HL, Roden D, Rodriguez LL, Williams MS, Cooper GM, Cox NJ, Herman GE, Kingsmore S, Lo C, Lutz C, MacRae CA, Nussbaum RL, Ordovas JM, Ramos EM, Robinson PN, Rubinstein WS, Seidman C, Stranger BE, Wang H, Westerfield M, Bult C. Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research. Cell. 2017 Mar 3/23/2017; 169(1): 6-12. PMID: 28340351, PMCID: PMC5511379, PII: S0092-8674(17)30284-2, DOI: 10.1016/j.cell.2017.03.005, ISSN: 1097-4172.