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Thatcher Heumann, M.D., M.P.H.

  • Assistant Professor of Medicine

Thatcher Heumann, M.D., M.P.H.

  • Assistant Professor of Medicine

thatcher.heumann@vumc.org

Profile

My career aims are to expand effective treatment options and improve outcomes for patients with GI malignancies through novel, early-phase clinical trials paired with excellent bedside care. Academically, my interests center on clinical-translational research focused on developing early-phase human trials, involving hypothesis-directed, novel combinatorial immunotherapies, paired with a rich translational focus. Prior to Oncology Fellowship, I piloted patient-outcome studies involving novel radiotherapy techniques in cutaneous T-cell lymphoma, adjuvant chemo-radiotherapy sequencing in high-risk endometrial cancer, and combination systemic therapy & stereotactic radiosurgery in melanoma with brain metastases. As a fellow at Johns Hopkins, under the guidance of my primary mentor in Fellowship, Dr. Nilofer Azad, my investigational focus and hands-on experience have centered on early-phase clinical trials examining novel mechanisms and treatment combinations to optimize immunogenicity in gastrointestinal cancers. I have led the efforts to design, author, and activate multiple investigator-initiated trials (IIT), including a CTEP-sponsored phase II trial that is now open ETCTN-wide. Being truly “bench to bedside,” both of my IITs are a result of partnering with my lab-based collaborators where I helped translate their promising preclinical findings to the realm of human trials. I currently help lead the hepatobiliary cancer team at Vanderbilt University where continue to test novel drugs and treatment combinations to optimize tumor response these patient populations. I am specifically interested in studying multi-agent immunotherapy-based treatment strategies targeting immune stimulation, tumor microenvironment modulation, and immune checkpoint blockade to help transform immune-resistant cancers into immunogenic tumors. It is my goal to form strong partnerships with lab-based investigators to bring promising pre-clinical findings to the bedside.

Education

  • M.D., Emory University, Atlanta, GA (2010)
  • M.P.H., Emory University, Atlanta, GA (2010)
  • B.A., Williams College, Williamstown, MA (2005)

Postdoctoral Training

  • Fellowship, Johns Hopkins University, Baltimore, MA (2019)
  • Residency, New York University, New York, NY (2016)

Research Emphasis

Research Description

Publications

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